The cycling gonad: retinoic-acid synthesis and degradation patterns during adult zebrafish Danio rerio oogenesis

• Type: Article in International Scientific Journal
• Date: 2018

Authors

Ruivo, R (Author) Other; Capitao, A (Author) Other; Filipe F C Castro (Author) FCUP; Santos, MM (Author) FCUP

Journal

Title: Journal of Fish Biology

Vol. 92

Pages: 1051-1064

ISSN: 0022-1112

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 7 Citations

Scopus - 8 Citations

Other information

Authenticus ID: P-00N-WJA

DOI: 10.1111/jfb.13564

Abstract (EN): The expression pattern of genes coding for enzymes of the retinoic acid (RA) synthetic and degradation pathways was characterized in adult female zebrafish Danio rerio. Females were conditioned until maturation and post-spawn expression dynamics were determined. A striking upregulation of cyp26b1, but not cyp26a1, was observed following egg deposition, decreasing to initial levels during recovery. A similar, yet lower, fluctuation was observed for aldh1a2 and rdh10a, the enzymes participating in the two-step RA biosynthesis cascade. The present work highlights the dynamics of the adult D. rerio oogenesis and uncovers novel, yet elusive, metabolic contributors. Possible compartmentalized roles for the different gene paralogue isoforms are discussed.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 14