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Coupling the cell-penetrating peptides transportan and transportan 10 to primaquine enhances its activity against liver-stage malaria parasites

Title
Coupling the cell-penetrating peptides transportan and transportan 10 to primaquine enhances its activity against liver-stage malaria parasites
Type
Article in International Scientific Journal
Year
2019
Authors
Aguiar, L
(Author)
Other
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Machado, M
(Author)
Other
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Sanches Vaz, M
(Author)
Other
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Prudencio, M
(Author)
Other
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Nuno Vale
(Author)
ICBAS
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Paula Gomes
(Author)
FCUP
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Journal
Title: MedChemCommImported from Authenticus Search for Journal Publications
Vol. 10
Pages: 221-226
ISSN: 2040-2503
Other information
Authenticus ID: P-00Q-8ZK
Abstract (EN): Novel primaquine-cell penetrating peptide conjugates were synthesised and tested in vitro against liver stage Plasmodium berghei parasites, showing that generally the conjugates were more active than the parent peptides and, in some cases, than the parent drug. These are unprecedented findings that may open a new route towards antimalarial drug rescuing.
Language: English
Type (Professor's evaluation): Scientific
No. of pages: 6
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