Biomimetic norfloxacin sensors made of molecularly-imprinted materials for potentiometric transduction

• Type: Article in International Scientific Journal
• Date: 2011

Authors

Moreira, FTC (Author) Other; Victor de Freitas (Author) FCUP; Sales, MGF (Author) Other

Journal

Title: Mikrochimica Acta

Vol. 172

Pages: 15-23

ISSN: 0026-3672

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 30 Citations

Scopus - 30 Citations

Other information

Authenticus ID: P-002-VCR

DOI: 10.1007/s00604-010-0464-4

Abstract (EN): A biomimetic sensor for norfloxacin is presented that is based on host-guest interactions and potentiometric transduction. The artificial host was imprinted into polymers made from methacrylic acid and/or 2-vinyl pyridine. The resulting particles were entrapped in a plasticized poly(vinyl chloride) (PVC) matrix. The sensors exhibit near-Nernstian response in steady state evaluations, and detection limits range from 0.40 to 1.0 mu g mL(-1), respectively, and are independent of pH values at between 2 and 6, and 8 and 11, respectively. Good selectivity was observed over several potential interferents. In flowing media, the sensors exhibit fast response, a sensitivity of 68.2 mV per decade, a linear range from 79 mu M to 2.5 mM, a detection limit of 20 mu g mL(-1), and a stable baseline. The sensors were successfully applied to field monitoring of norfloxacin in fish samples, biological samples, and pharmaceutical products. vertical bar

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9