CHOROIDAL THICKNESS IN DIABETIC PATIENTS WITHOUT DIABETIC RETINOPATHY

• Type: Article in International Scientific Journal
• Date: 2018

Authors

Ferreira, JT (Author) Other; Vicente, A (Author) Other; Proenca, R (Author) Other; Santos, BO (Author) Other; Cunha, JP (Author) Other; Alves, M (Author) Other; Papoila, AL (Author) Other; Pinto, LA (Author) Other

Journal

Title: Retina

Vol. 38

Pages: 795-804

ISSN: 0275-004X

Publisher: Wolters Kluwer Health

Indexing

ISI Web of Knowledge - 9 Citations

Other information

Authenticus ID: P-00P-DRQ

DOI: 10.1097/iae.0000000000001582

Abstract (EN): Purpose: To compare choroidal thickness (CT) between diabetic patients without diabetic retinopathy and a nondiabetic group. To explore how CT relates to disease duration, mean arterial pressure, glycemia, glycosylated hemoglobin, intraocular pressure, and ocular pulse amplitude. Methods: Choroidal thickness was assessed using a spectral-domain optical coherence tomography and enhanced depth mode at 13 locations (subfoveal and 3 measurements 500 mu m apart in 4 directions-nasal, temporal, superior, and inferior). Linear regression models were used. Results: One hundred seventy-five patients were recruited (125 diabetic patients without diabetic retinopathy and 50 nondiabetic patients). In diabetic patients, although without statistical significance, CT showed a trend to be thicker in all locations (6.16-24.27 mu m). Choroidal thickness was negatively associated with age (P < 0.001) in both groups, but only in the diabetic group, it was positively associated to ocular pulse amplitude (with a mean increase between 8.5 mu m and 11.6 mu m for each millimeter of mercury increase in ocular pulse amplitude). Diabetic patients' CT seems to stabilize after 150 months of diabetes, increase with higher glycemia levels (>160 mg/dL) while showing no fluctuation with glycosylated hemoglobin and mean arterial pressure. Conclusion: There seems to be a thickening of the choroid in diabetic patients without diabetic retinopathy. Moreover, this tissue may be functionally different in diabetes, as the pattern of associations seems to differ between groups.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 10