Exercise training protects against cancer-induced cardiac remodeling in an animal model of urothelial carcinoma

• Type: Article in International Scientific Journal
• Date: 2018

Authors

Ana Isabel Padrão (Author) FADEUP; Rita Nogueira-Ferreira (Author) Other; Rui Vitorino (Author) Other; Dulce Carvalho (Author) Other; Catarina Correia (Author) Other; Maria João Neuparth (Author) Other; Maria João Pires (Author) Other; Ana Isabel Faustino-Rocha (Author) Other; Lúcio Lara Santos (Author) Other; Paula Alexandra Oliveira (Author) Other; José Alberto Duarte (Author) FADEUP; Daniel Moreira-Goncalves (Author) Other; Rita Ferreira (Author) Other

Journal

Title: Archives of Biochemistry and Biophysics

Vol. 645

Pages: 12-18

ISSN: 0003-9861

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 10 Citations

Scopus - 12 Citations

Scientific classification

FOS: Social sciences

Other information

Authenticus ID: P-00N-QXB

DOI: 10.1016/j.abb.2018.03.013

Abstract (EN): Limiting cancer-induced cardiac damage has become an increasingly important issue to improve survival rates and quality of life. Exercise training has been shown to reduce cardiovascular complications in several diseases; however, its therapeutic role against cardiovascular consequences of cancer is in its infancy. In order to add new insights on the potential therapeutic effect of exercise training on cancer-related cardiac dysfunction, we used an animal model of urothelial carcinoma submitted to 13 weeks of treadmill exercise after 20 weeks of exposure to the carcinogenic N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN). Data showed that 13 weeks of treadmill exercise reverted cancer-induced cardiomyocytes atrophy and fibrosis, improved cardiac oxidative capacity given by citrate synthase activity and MnSOD content, and increased the levels of the mitochondrial biogenesis markers PGC-1 alpha and mtTFA. Moreover, exercise training reverted cancer-induced decrease of cardiac c-kit levels suggesting enhanced regenerative ability of heart. These cardiac adaptations to exercise were related to a lower incidence of malignant urothelial lesions and less signs of inflammation. Taken together, data from the present study support the beneficial effect of exercise training when started after cancer diagnosis, envisioning the improvement of the cardiovascular function.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7