8-Foot-Up-and-Go Test is associated with hospitalizations and mortality in idiopathic pulmonary fibrosis: a prospective pilot study

• Type: Article in International Scientific Journal
• Date: 2019

Authors

Baruch Vainshelboim (Author) Other; Mordechai Reuven Kramer (Author) Other; Jonathan Myers (Author) Other; Avraham Unterman (Author) Other; Shimon Izhakian (Author) Other; José Oliveira (Author) FADEUP

Journal

Title: Lung

Vol. 197 No. 1

Pages: 81-88

ISSN: 0341-2040

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 3 Citations

Scopus - 3 Citations

Scientific classification

FOS: Social sciences

Other information

Authenticus ID: P-00Q-274

DOI: 10.1007/s00408-018-0189-4

Abstract (EN): Purpose To assess the prognostic value of the 8-foot-up-and-go test (8-FUGT) in pilot cohort of patients with idiopathic pulmonary fibrosis (IPF). Methods Thirty-four patients with IPF (68 +/- 8 years) underwent 8-FUGT at baseline and were followed for up to 40 months. Receiver operating characteristics and age-adjusted Cox hazard ratios (HR) were analyzed for 8-FUGT, hospitalizations, and mortality. Correlation coefficients were determined between 8-FUGT and other exercise tests. Results 8-FUGT >= 6.9 s was found to be associated with hospitalization (sensitivity = 77%, specificity = 76%, p = 0.03) and mortality (sensitivity = 91%, specificity = 70% p = 0.008) in patients with IPF. Categorical models demonstrated that 8-FUGT >= 6.9 s was associated with 14.1 - (p < 0.001) and 55.4-fold (p = 0.001) increased risks for hospitalization and mortality, respectively. In continuous models, for every 1-s slower performance in the 8-FUGT there were 54% [HR = 1.54, 95% CI (1.11-2.15) p = 0.01] increased risk for hospitalization and 94% [HR = 1.94, 95% CI (1.26-2.99) p = 0.003] increased risk for mortality. 8-FUGT was inversely related to 6-min walk distance (r = -0.61), peak oxygen consumption (r = -0.58), and peak work rate (r = -0.72), all p < 0.001. Conclusions The 8-FUGT was strongly associated with hospitalizations and mortality in patients with IPF, as well as correlated with established prognostic markers. These novel findings suggest a prognostic value of the 8-FUGT for risk stratification, referral to pulmonary rehabilitation, and considering listing for lung transplantation. 8-FUGT is an inexpensive and practical tool that has prospective for implementation in clinical and research settings in IPF. Future prospective studies should evaluate the effect of changes in 8-FUGT on clinical outcomes.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8