MicroRNAs and altered metabolism of clear cell renal cell carcinoma: Potential role as aerobic glycolysis biomarkers

• Type: Another Publication in an International Scientific Journal
• Date: 2017

Authors

Morais, M (Author) Other; Dias, F (Author) Other; Teixeira, AL (Author) Other; Rui Medeiros (Author) ICBAS

Journal

Title: Biochimica et Biophysica Acta - General Subjects

Vol. 1861

Pages: 2175-2185

ISSN: 0304-4165

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 26 Citations

Other information

Authenticus ID: P-00M-XBG

DOI: 10.1016/j.bbagen.2017.05.028

Abstract (EN): Background: Warburg Effect is a metabolic switch that occurs in most of cancer cells but its advantages are not fully understood. This switch is known to happen in renal cell carcinoma (RCC), which is the most common solid cancer of the adult kidney. RCC carcinogenesis is related to pVHL loss and Hypoxia Inducible Factor (HIF) activation, ultimately leading to the activation of several genes related to glycolysis. MicroRNAs (miRNAs) regulate gene expression at a post-transcriptional level and are also deregulated in several cancers, including RCC. Scope of review: This review focuses in the miRNAs that direct target enzymes involved in glycolysis and that are deregulated in several cancers. It also reviews the possible application of miRNAs in the improvement of clinical patients' management. Major conclusions: Several miRNAs that direct target enzymes involved in glycolysis are downregulated in cancer, strongly influencing the Warburg Effect Due to this strong influence, FDG-PET can possibly benefit from measurement of these miRNAs. Restoring their levels can also bring an improvement to the current therapies.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 11