Post-transplant lymphoproliferative disorder in hematopoietic stem cell transplant patients: A single center retrospective study between 2005 and 2012

• Type: Article in International Scientific Journal
• Date: 2018

Authors

Marinho Dias, J (Author) Other; Lobo, J (Author) Other; henrique, rmf (Author) ICBAS; Baldaque, I (Author) Other; Pinho Vaz, C (Author) Other; Regadas, L (Author) Other; Branca, R (Author) Other; Campilho, F (Author) Other; Campos, A (Author) Other; Rui Medeiros (Author) ICBAS; Sousa, H (Author) Other

Journal

Title: Molecular Medicine Reports

Vol. 18

Pages: 4650-4656

ISSN: 1791-2997

Publisher: Spandidos Publications

Indexing

ISI Web of Knowledge - 2 Citations

Scopus - 3 Citations

Other information

Authenticus ID: P-00P-NS9

DOI: 10.3892/mmr.2018.9433

Abstract (EN): Post-transplant lymphoproliferative disorder (PTLD), despite its rarity, is an important mortality/morbidity event in transplant patients. The purpose of the present study was to retrospectively examine the clinical and pathologic characteristics, and outcomes of PTLD at the Portuguese Oncology Institute of Porto. A retrospective review of patient information was performed for patients that developed PTLD following allogeneic hematopoietic stem cell transplant (aHSCT) and were diagnosed between 2005 and 2012. The present study included a total of 15 patients, 8 females (53.3%) and 7 males (46.7%), with different clinicopathological characteristics. The most frequent clinical condition inducing aHSCT was acute lymphocytic leukemia (40.0%). Conditioning regimens consisted primarily in busulfan and cyclophosphamide, with anti-thymocyte globulin, and myeloablation was the preferential treatment. Epstein-Barr virus (EBV) was present in all patients with a median time of diagnosis following transplant of 75 days (range, 25-485 days) and a median viral load of 4.75 log(10) copies/ml (range, 3.30-6.26 log(10) copies/ml). PTLD diagnosis was mainly assessed by clinical findings, and histological confirmation was available for 5 patients: 3 monomorphic, 1 polymorphic and 1 with early lesions of PTLD. To the best of our knowledge, this is the first study to describe PTLD cases in HSCT patients in Portugal. The data reinforces the importance of performing EBV monitoring in high-risk patients, particularly those receiving a transplant from mismatch/unrelated donors, and those with myeloablative conditioning regimen including antithymocyte globulin. The results also suggested that EBV viral load may be significant for the prediction of PTLD development.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7