Canine mammary tumor risk is associated with polymorphisms in RAD51 and STK11 genes

• Type: Article in International Scientific Journal
• Date: 2018

Authors

Canadas, A (Author) Other; Santos, M (Author) Other; Nogueira, A (Author) Other; Assis, J (Author) Other; Gomes, M (Author) Other; Carolina Lemos (Author) ICBAS; Rui Medeiros (Author) ICBAS; Dias Pereira, P (Author) Other

Journal

Title: Journal of Veterinary Diagnostic Investigation

Vol. 30

Pages: 733-738

ISSN: 1040-6387

Publisher: SAGE

Indexing

ISI Web of Knowledge - 15 Citations

Scopus - 16 Citations

Other information

Authenticus ID: P-00P-385

DOI: 10.1177/1040638718789231

Abstract (EN): Cancer is a complex disease involving genetic and phenotypic changes. Several single nucleotide polymorphisms (SNPs) have been associated with the risk of breast cancer development in women; however, little is known regarding their influence on canine mammary tumor risk. We assessed the influence of SNPs in genes related to human breast cancer susceptibility, with respect to the risk of development of mammary tumors in dogs. Sixty-seven canine SNPs in proto-oncogenes, tumor suppressor genes, genes involved in DNA repair, and in hormonal metabolism were evaluated in 212 bitches with mammary tumors and in 161 bitches free of mammary neoplasia. A significant association with mammary neoplasia risk was identified for 2 SNPs in RAD51 (rs23623251 and rs23642734) and one SNP in the STK11 gene (rs22928814). None of the other SNPs were related to the risk of mammary tumor development. The identification of genetic profiles associated with risk of mammary neoplasia is of great importance, supporting the implementation of specific clinical management strategies in high-risk animals.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6