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Mucosal immunization confers long-term protection against intragastrically established Neospora caninum infection

Title
Mucosal immunization confers long-term protection against intragastrically established Neospora caninum infection
Type
Article in International Scientific Journal
Year
2016
Authors
Ferreirinha, P
(Author)
Other
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Teixeira Coelho, M
(Author)
Other
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Osorio, H
(Author)
Other
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Rocha, A
(Author)
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Manuel Vilanova
(Author)
ICBAS
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Journal
Title: VaccineImported from Authenticus Search for Journal Publications
Vol. 34
Pages: 6250-6258
ISSN: 0264-410X
Publisher: Elsevier
Other information
Authenticus ID: P-00M-9Y3
Abstract (EN): Neospora caninum is an obligate intracellular protozoan parasite responsible for heavy economic losses in dairy and beef cattle farms worldwide. Although vaccination is widely regarded as the preferable strategy to prevent neosporosis no commercial vaccine is currently available. We have previously shown that intranasal immunization with an N. caninum antigen extract enriched in hydrophobic proteins plus CpG adjuvant protected mice against intragastrically established neosporosis. Nevertheless, the antigen specificity as well as the long-term protective effect of this immunization strategy were not determined. Here, we show that the protective effect of this intranasal immunization procedure lasted for at least 20 weeks. Protection was accompanied by long-lasting elevated levels of parasite-specific serum IgG and intestinal IgA. Moreover, spleen and mesenteric lymph node cells obtained from non-infected long-term immunized mice responded by producing interferon-gamma following in vitro parasite-antigen recall. Analysis of serum IgG and intestinal IgA antibody reactivity in immunized mice identified dense granule antigen 7 (NcGRA7) and microneme associated protein 1 (NcMIC1) as immunodominant antigens respectively recognized by those antibody fractions. In summary, this work shows that a previously reported mucosal immunization strategy against N. caninum infection established through the gastrointestinal tract is effective in the long term.
Language: English
Type (Professor's evaluation): Scientific
No. of pages: 9
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