Modelling the suppression of autoimmunity after pathogen infection

• Type: Article in International Scientific Journal
• Date: 2018

Authors

Oliveira, B.M.P.M. (Author) FCNAUP; Trinchet, R (Author) Other; Otero Espinar, MV (Author) Other; Pinto, Aberto A. (Author) FCUP; Burroughs, N (Author) Other

Journal

Title: Mathematical Methods in the Applied Sciences

Vol. 41

Pages: 8565-8570

ISSN: 0170-4214

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 5 Citations

Scopus - 5 Citations

Scientific classification

CORDIS: Physical sciences > Mathematics

FOS: Natural sciences > Mathematics

Other information

Authenticus ID: P-00P-Y6T

DOI: 10.1002/mma.4899

Abstract (EN): We study a mathematical model of immune response by T cells where the regulatory T cells (Treg) inhibit interleukin 2 (IL-2) secretion. We model the suppression of the autoimmune line of T cells after a different line of T cells responded to a pathogen infection. In this paper, we show that if the population of the pathogen responding line of T cells becomes large enough, the competition for IL-2 and the increase in the death rates may lead to a depletion in the concentration of autoimmune T cells. Provided this lasts for a sufficiently long time, the concentration of autoimmune T cells can be brought down to values inside the basin of attraction of the controlled state, and autoimmunity can be suppressed. Copyright © 2018 John Wiley & Sons, Ltd.

Language: English

Type (Professor's evaluation): Scientific