Quality of Vancomycin for Injection Formulations in Brazil

• Type: Article in International Scientific Journal
• Date: 2019

Authors

Secco, G (Author) Other; Sachetti, C (Author) Other; Rossato Grando, LG (Author) Other; Hahn, SR (Author) Other; Pagnussat, LR (Author) Other; Fresco, P (Author) FFUP; Bertol, CD (Author) Other

Journal

Title: Current Pharmaceutical Analysis

Vol. 15

Pages: 280-285

ISSN: 1573-4129

Publisher: Bentham Science

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 0 Citations

Other information

Authenticus ID: P-00N-KJ4

DOI: 10.2174/1573412914666180116143232

Abstract (EN): Background: The presence of impurities in vancomycin compromised the safety and contributed to decrease of its use for years. In Brazil, vancomycin generic drug represents an option to reduce hospital costs. However, the controversy over the quality of these formulations and their relationship to effectiveness and safety raised concerns. Objective and Methods: To assess in vitro quality of vancomycin injections through uniformity of weight, pH, clarity of solution, microbiological assay and impurities determination by High Performance Liquid Chromatography (HPLC). Results: The samples were approved in the tests. Conclusion: The injectable formulations of vancomycin proved to be safe for use in hospital environment. This work contributes to increase health professional's confidence on generic vancomycin.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6