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Emerging Concepts in Gastric Neoplasia: Heritable Gastric Cancers and Polyposis Disorders

Title
Emerging Concepts in Gastric Neoplasia: Heritable Gastric Cancers and Polyposis Disorders
Type
Another Publication in an International Scientific Journal
Year
2017
Authors
van der Post, RS
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Carneiro F
(Author)
FMUP
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Journal
Vol. 10
Pages: 931-945
ISSN: 1875-9181
Publisher: Elsevier
Indexing
Other information
Authenticus ID: P-00N-8T3
Abstract (EN): Hereditary gastric cancer is a relatively rare disease with specific clinical and histopathologic characteristics. Hereditary gastric cancer of the diffuse type is predominantly caused by germline mutations in CDH1. The inherited cause of familial intestinal gastric cancer is unknown. Gastric adenocarcinoma and proximal polyposis of the stomach is a hereditary cancer syndrome caused by germline mutations in promoter 1B of APC. Other well-defined cancer syndromes, such as Lynch, Li-Fraumeni, and hereditary breast or ovarian cancer syndromes, are associated with increased risk of gastric cancer. This article reviews important histopathologic features and emerging concepts regarding gastric carcinogenesis in these syndromes. © 2017 Elsevier Inc.
Language: English
Type (Professor's evaluation): Scientific
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