CRISPR-Cas9 therapies in experimental mouse models of cancer

• Type: Article in International Scientific Journal
• Date: 2018

Authors

Diogo Estêvão (Author) Other; Natália Rios Costa (Author) Other; Rui Gil da Costa (Author) FEUP; Rui Medeiros (Author) Other

Journal

Title: Future Oncology

Vol. 14 No. 20

Pages: 1-13

ISSN: 1479-6694

Publisher: Future Medicine Ltd.

Indexing

ISI Web of Knowledge - 3 Citations

Scopus - 4 Citations

Other information

Authenticus ID: P-00P-HV1

DOI: 10.2217/fon-2018-0028

Abstract (EN): The CRISPR-Cas9, a part of the defence mechanism from bacteria, has rapidly become the simplest, fastest and the most precise genome-editing tool available. The therapeutic applications of CRISPR are boundless: correction of mutations in several disorders, inactivation of oncogenes and viral oncoproteins, and activation of tumor suppressor genes. In this review, we expose recent advances concerning animal models of cancer that use CRISPR-Cas9, addressing also the current efforts to develop CRISPR-Cas9-based therapies, focusing on proof-of-concept studies. Finally, the review exposes some of the main challenges that this genome-editing tool faces. The key issue remains: does CRISPR-Cas9 have real potential for therapeutic application or will it just remain a wonderful research tool?

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 13