The N-butyl-N-4-hydroxybutyl nitrosamine mouse urinary bladder cancer model

• Type: Chapter or Part of a Book
• Date: 2018

Authors

Paula A. Oliveira (Author) Other; Cármen Vasconcelos Nóbrega (Author) Other; Rui M. Gil da Costa (Author) FEUP; Regina Arantes Rodrigues (Author) Other

Book

Title: Urothelial Carcinoma. Methods in Molecular Biology

Pages: 155-167

Publisher: Humana Press

Indexing

Scopus

Other information

DOI: 10.1007/978-1-4939-7234-0_13

Abstract (EN): Urinary bladder cancer (UBC) is a common and complex malignancy, with a multifactorial etiology, like environmental factors, such as cigarette smoking, occupational exposure, and genetic factors. UBC exhibits considerable genotypic and phenotypic heterogeneity. Among all UBC lesions, urothelial carcinoma is the most frequently observed histological type. Despite all the developments made in urologic oncology field, therapeutic options remain inadequate. There is urgency for the identification and development of new antineoplastic drugs to replace or improve current protocols and in vivo models have been proven to be essential for this step. There are different animal models of UBC: Spontaneous and experimentally induced models (genetically engineered, transplantable-xenograft and syngeneic animals- and chemically induced models). N-butyl-N(4-hydroxybutil)nitrosamine (BBN) is the most suitable reagent to generate chemically induced in vivo models of UBC and to study bladder carcinogenesis. BBN has proven, over the years, to be very realistic and reliable. It is bladder specific, and induces high tumor incidence. © Springer Science+Business Media LLC 2018.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 13