Mitochondria: Targeting mitochondrial reactive oxygen species with mitochondriotropic polyphenolic-based antioxidants

• Type: Article in International Scientific Journal
• Date: 2018

Authors

Teixeira, J (Author) Other; Deus, CM (Author) Other; Fernanda Borges (Author) FCUP; Oliveira, PJ (Author) Other

Journal

Title: International Journal of Biochemistry and Cell Biology

Vol. 97

Pages: 98-103

ISSN: 1357-2725

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 23 Citations

Scopus - 30 Citations

Other information

Authenticus ID: P-00N-MXJ

DOI: 10.1016/j.biocel.2018.02.007

Abstract (EN): Mitochondrial function and regulation of redox balance is fundamental in controlling cellular life and death pathways. Antioxidants have been used to counteract disruption of redox networks, normally associated with progressive loss of cell homeostasis and disease pathophysiology, although therapeutic success is limited mainly due to pharmacokinetic drawbacks. Attempts to improve mitochondrial function in a range of diseases spurred active drug discovery efforts. Currently, the most effective strategy to deliver drugs to mitochondria is the covalent link of lipophilic cations to the bioactive compound. Although targeting mitochondrial oxidative stress with antioxidants has been demonstrated, clinical use has been hampered by several challenges, with no FDA approved drug so far. Development of new mitochondriotropic antioxidant agents based on dietary polyphenols has recently gained momentum. Due to their nature, mitochondria-targeted multi-functional antioxidants can trigger stress responses and contribute to tissue protection through hormesis mechanisms, inhibiting excessive mitochondrial ROS production and associated diseases.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6