Gold nanoparticles for targeting varlitinib to human pancreatic cancer cells

• Type: Article in International Scientific Journal
• Date: 2018

Authors

Sílvia Castro Coelho (Author) FEUP; Daniel Pires Reis (Author) Other; Maria do Carmo Pereira (Author) FEUP; Manuel A. N. Coelho (Author) FEUP

Journal

Title: Pharmaceutics

Vol. 10 No. 3

Pages: 1-12

ISSN: 1999-4923

Publisher: MDPI

Indexing

ISI Web of Knowledge - 2 Citations

Scopus - 8 Citations

Associated Projects

LEPABE - Laboratório de Engenharia de Processos, Ambiente, Biotecnologia e Energia

NanoEFEct - Nanoparticle enhanced molecular Fluorescence-Endoscopy for detection of early stage colorectal adenocarcinoma

Other information

Authenticus ID: P-00P-JCS

DOI: 10.3390/pharmaceutics10030091

Abstract (EN): Colloidal gold nanoparticles are targeting probes to improve varlitinib delivery into cancer cells. The nanoconjugates were designed by the bioconjugation of pegylated gold nanoparticles with varlitinib via carbodiimide-mediated cross-linking and characterized by infrared and X-ray photoelectron spectroscopy. The drug release response shows an initial delay and a complete drug release after 72 h is detected. In vitro experiments with MIA PaCa-2 cells corroborate that PEGAuNPsVarl conjugates increase the varlitinib toxic effect at very low concentrations (IC50 = 80 nM) if compared with varlitinib alone (IC50 = 259 nM). Our results acknowledge a decrease of drug side effects in normal cells and an enhancement of drug efficacy against to the pancreatic cancer cells reported. © 2018 by the authors. Licensee MDPI, Basel, Switzerland.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 12