The Genetics of Papillary Microcarcinomas of the Thyroid: Diagnostic and Prognostic Implications

• Type: Another Publication in an International Scientific Journal
• Date: 2017

Authors

Rodrigues, AC (Author) Other; Penna, G (Author) Other; Rodrigues, E (Author) Other; Castro, P (Author) Other; Sobrinho Simoes, M (Author) Other; Soares, P (Author) FMUP

Journal

Title: Current Genomics

Vol. 18

Pages: 244-254

ISSN: 1389-2029

Publisher: Bentham Science

Indexing

ISI Web of Knowledge - 19 Citations

Scopus - 21 Citations

Other information

Authenticus ID: P-00N-F9S

DOI: 10.2174/1389202918666170105094459

Abstract (EN): Papillary microcarcinoma of the thyroid (mPTC) is defined by the WHO as a papillary thyroid cancer measuring 10mm or less in diameter and it is nowadays a topic of intense debate among the members of the medical community due to its apparent "epidemic" rise. Although these tumors follow almost always an indolent clinical course and carry an excellent prognosis, it is known that a small subset may display a potentially aggressive behavior. Nevertheless, we still lack an accurate way of predicting those which will cause significant disease. In an attempt to address this problem, a number of clinico-pathologic features have been studied as poor prognostic markers in mPTC, and their association with known genetic alterations in thyroid cancer has been evaluated. Herein we review the present knowledge concerning mPTC's genetic profile, namely the prevalence of BRAF (V600E), RAS and TERT promoter mutations and RET/PTC and PAX8-PPARG rearrangements and report the results of the evaluation in the putative prognostic value of these genetic alterations in mPTC.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 11