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Etiopathogenesis of oncocytomas

Title
Etiopathogenesis of oncocytomas
Type
Another Publication in an International Scientific Journal
Year
2017
Authors
Correia, M
(Author)
Other
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Pinheiro, P
(Author)
Other
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Batista, R
(Author)
Other
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Sobrinho Simoes, M
(Author)
Other
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Maximo, V
(Author)
FMUP
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Journal
Vol. 47
Pages: 82-94
ISSN: 1044-579X
Publisher: Elsevier
Other information
Authenticus ID: P-00N-BC2
Abstract (EN): Oncocytomas are distinct tumors characterized by an abnormal accumulation of defective and (most probably) dysfunctional mitochondria in cell cytoplasm of such tumors. This particular phenotype has been studied for the last decades and the clarification of the etiopathogenic causes are still needed. Several mechanisms involved in the formation and maintenance of oncocytomas are accepted as reasonable causes, but the relevance and contribution of each one for oncocytic transformation may depend on different cancer etiopathogenic contexts. In this review, we describe the current knowledge of the etiopathogenic events that may lead to oncocytic transformation and discuss their contribution for tumor progression and mitochondrial accumulation.
Language: English
Type (Professor's evaluation): Scientific
No. of pages: 13
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