Etiopathogenesis of oncocytomas

• Type: Another Publication in an International Scientific Journal
• Date: 2017

Authors

Correia, M (Author) Other; Pinheiro, P (Author) Other; Batista, R (Author) Other; Soares, P (Author) FMUP; Sobrinho Simoes, M (Author) Other; Maximo, V (Author) FMUP

Journal

Title: Seminars in Cancer Biology

Vol. 47

Pages: 82-94

ISSN: 1044-579X

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 7 Citations

Scopus - 9 Citations

Other information

Authenticus ID: P-00N-BC2

DOI: 10.1016/j.semcancer.2017.06.014

Abstract (EN): Oncocytomas are distinct tumors characterized by an abnormal accumulation of defective and (most probably) dysfunctional mitochondria in cell cytoplasm of such tumors. This particular phenotype has been studied for the last decades and the clarification of the etiopathogenic causes are still needed. Several mechanisms involved in the formation and maintenance of oncocytomas are accepted as reasonable causes, but the relevance and contribution of each one for oncocytic transformation may depend on different cancer etiopathogenic contexts. In this review, we describe the current knowledge of the etiopathogenic events that may lead to oncocytic transformation and discuss their contribution for tumor progression and mitochondrial accumulation.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 13