Frontiers in endocrine disruption: Impacts of organotin on the hypothalamus-pituitary-thyroid axis

• Type: Article in International Scientific Journal
• Date: 2018

Authors

Santos Silva, AP (Author) Other; Andrade, MN (Author) Other; Pereira Rodrigues, P (Author) Other; Paiva Melo, FD (Author) Other; Soares, P (Author) FMUP; Graceli, JB (Author) Other; Dias, GRM (Author) Other; Ferreira, ACF (Author) Other; de Carvalho, DP (Author) Other; Miranda Alves, L (Author) Other

Journal

Title: Molecular and Cellular Endocrinology

Vol. 460

Pages: 246-257

ISSN: 0303-7207

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 45 Citations

Scopus - 56 Citations

Other information

Authenticus ID: P-00N-F9T

DOI: 10.1016/j.mce.2017.07.038

Abstract (EN): Endocrine disruptors (EDs), chemical substances widely used in industry and ubiquitously distributed in the environment, are able to interfere with the synthesis, release, transport, metabolism, receptor binding, action, or elimination of endogenous hormones. EDs affect homeostasis mainly by acting on nuclear and nonnuclear steroid receptors but also on serotonin, dopamine, norepinephrine and orphan receptors in addition to thyroid hormone receptors. Tributyltin (TBT), an ED widely used as a pesticide and biocide in antifouling paints, has well-documented actions that include inhibiting aromatase and affecting the nuclear receptors PPAR gamma and RXR. TBT exposure in humans and experimental models has been shown to mainly affect reproductive function and adipocyte differentiation. Since thyroid hormones play a fundamental role in regulating the basal metabolic rate and energy homeostasis, it is crucial to clarify the effects of TBT on the hypothalamus-pituitary-thyroid axis. Therefore, we review herein the main effects of TBT on important metabolic pathways, with emphasis on disruption of the thyroid axis that could contribute to the development of endocrine and metabolic disorders, such as insulin resistance and obesity.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 12