Solid and aqueous magnetoliposomes as nanocarriers for a new potential drug active against breast cancer

• Type: Article in International Scientific Journal
• Date: 2017

Authors

Rodrigues, ARO (Author) Other; Mendes, PMF (Author) Other; Silva, PML (Author) Other; Machado, VA (Author) Other; Almeida, BG (Author) Other; araujo, j. p. (Author) FCUP; Queiroz, MJRP (Author) Other; Castanheira, EMS (Author) Other; Coutinho, PJG (Author) Other

Journal

Title: Colloids and Surfaces B: Biointerfaces

Vol. 158

Pages: 460-468

ISSN: 0927-7765

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 14 Citations

Other information

Authenticus ID: P-00N-6GM

DOI: 10.1016/j.colsurfb.2017.07.015

Abstract (EN): Iron oxide nanoparticles, with diameters around 12 nm, were synthesized by coprecipitation method. The magnetic properties indicate a superparamagnetic behavior with a coercive field of 9.7 Oe and a blocking temperature of 118 K. Both aqueous and solid magnetoliposomes containing magnetite nanoparticles have sizes below 150 nm, suitable for biomedical applications. Interaction between both types of magnetoliposomes and models of biological membranes was proven. A new antitumor compound, a diarylurea derivative of thienopyridine, active against breast cancer, was incorporated in both aqueous and solid magnetoliposomes, being mainly located in the lipid membrane. A promising application of these magnetoliposomes in oncology is anticipated, allowing a combined therapeutic approach, using both chemotherapy and magnetic hyperthermia.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9