Longer duration of obesity is associated with a reduction in urinary angiotensinogen in prepubertal children

• Type: Article in International Scientific Journal
• Date: 2017

Authors

Morato, M (Author) FFUP; Correia Costa, L (Author) Other; Sousa, T (Author) FMUP; Cosme, D (Author) Other; Schaefer, F (Author) Other; Areias JC (Author) FMUP; Antonio Guerra (Author) FMUP; Alberto Caldas Afonso (Author) ICBAS; Barros H (Author) FMUP; Azevedo A (Author) FMUP; Albino Teixeira, A (Author) FMUP

Journal

Title: Pediatric Nephrology

Vol. 32

Pages: 1411-1422

ISSN: 0931-041X

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 3 Citations

Scopus - 3 Citations

Other information

Authenticus ID: P-00M-KT7

DOI: 10.1007/s00467-017-3639-y

Abstract (EN): We aimed to study the impact of obesity on urinary excretion of angiotensinogen (U-AGT) in prepubertal children, focusing on the duration of obesity and gender. Also, we aimed to evaluate whether plasma angiotensinogen (P-AGT) and hydrogen peroxide (H2O2) play a role in the putative association. Cross-sectional evaluation of 305 children aged 8-9 years (160 normal weight, 86 overweight, and 59 obese). Anthropometric measurements and 24-h ambulatory blood pressure monitoring were performed. Angiotensinogen (AGT) was determined by a commercial enzyme-linked immunosorbent assay (ELISA) kit and H2O2 by a microplate fluorometric assay. U-AGT and P-AGT levels were similar across body mass index (BMI) groups and between sexes. However, boys who were overweight/obese since the age of 4 years presented lower levels of U-AGT compared with those of normal weight at the same age. In children who were overweight/obese since the age of 4, urinary H2O2 decreased with P-AGT. A higher duration of obesity was associated with decreased U-AGT in boys, thus reflecting decreased intrarenal activity of the renin-angiotensin system. Also, children with a longer duration of obesity showed an inverse association between urinary H2O2 and P-AGT. Future studies should address whether these results reflect an early compensatory mechanism to limit obesity-triggered renal dysfunction.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 12