Autonomic dysfunction affects cerebral neurovascular coupling

• Type: Article in International Scientific Journal
• Date: 2011

Authors

Elsa Azevedo (Author) FMUP; Pedro Castro (Author) FMUP; Santos, R (Author) Other; Freitas, J (Author) FMUP; Coelho, T (Author) Other; Rosengarten, B (Author) Other; Panerai, R (Author) Other

Journal

Title: Clinical Autonomic Research

Vol. 21

Pages: 395-403

ISSN: 0959-9851

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 37 Citations

Scopus - 38 Citations

Other information

Authenticus ID: P-002-JD7

DOI: 10.1007/s10286-011-0129-3

Abstract (EN): Autonomic failure (AF) affects the peripheral vascular system, but little is known about its influence on cerebrovascular regulation. Patients with familial amyloidotic polyneuropathy (FAP) were studied as a model for AF. Ten mild (FAPm), 10 severe (FAPs) autonomic dysfunction FAP patients, and 15 healthy controls were monitored in supine and sitting positions for arterial blood pressure (ABP) and heart rate (HR) with arterial volume clamping, and for blood flow velocity (BFV) in posterior (PCA) and contralateral middle cerebral arteries (MCA) with transcranial Doppler. Analysis included resting BFV, cerebrovascular resistance parameters (cerebrovascular resistance index, CVRi; resistance area product, RAP; and critical closing pressure, CrCP), and neurovascular coupling through visually evoked BFV responses in PCA (gain, rate time, attenuation, and natural frequency). In non-stimulation conditions, in each position, there were no significant differences between the groups, regarding HR, BP, resting BFV, and vascular resistance parameters. Sitting ABP was higher than in supine in the three groups, although only significantly in controls. Mean BFV was lower in sitting in all the groups, lacking statistical significance only in FAPs PCA. CVRi and CrCP increased with sitting in all the groups, while RAP increased in controls but decreased in FAPm and FAPs. In visual stimulation conditions, FAPs comparing to controls had a significant decrease of natural frequency, in supine and sitting, and of rate time and gain in sitting position. These results demonstrate that cerebrovascular regulation is affected in FAP subjects with AF, and that it worsens with orthostasis.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9