New chiral stationary phases based on xanthone derivatives for liquid chromatography

• Type: Article in International Scientific Journal
• Date: 2017

Authors

Carla Fernandes (Author) FFUP; Tiritan M.E. (Author) FFUP; Sara Cravo (Author) FFUP; Phyo, YZ (Author) Other; Kijjoa, A (Author) Other; Silva, AMS (Author) Other; Cass, QB (Author) Other; Pinto, MMM (Author) Other

Journal

Title: Chirality

Vol. 29

Pages: 430-442

ISSN: 0899-0042

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 14 Citations

Scopus - 15 Citations

Other information

Authenticus ID: P-00N-NH2

DOI: 10.1002/chir.22706

Abstract (EN): Six chiral derivatives of xanthones (CDXs) were covalently bonded to silica, yielding the corresponding xanthonic chiral stationary phases (XCSPs). The new XCSPs were packed into stainless-steel columns with 150 x 4.6 mm i.d. Moreover, the greening of the chromatographic analysis by reducing the internal diameter (150 x 2.1 mm i.d.) of the liquid chromatography (LC) columns was also investigated. The enantioselective capability of these phases was evaluated by LC using different chemical classes of chiral compounds, including several types of drugs. A library of CDXs was evaluated in order to explore the principle of reciprocity as well as the chiral self-recognition phenomenon. The separation of enantiomeric mixtures of CDXs was investigated under multimodal elution conditions. The XCSPs provided high specificity for the enantiomeric mixtures of CDXs evaluated mainly under normal-phase elution conditions. Furthermore, two XCSPs were prepared with both enantiomers of the same xanthonic selector in order to confirm the inversion order elution.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 13