Chiral Separation in Preparative Scale: A Brief Overview of Membranes as Tools for Enantiomeric Separation

• Type: Another Publication in an International Scientific Journal
• Date: 2017

Authors

Carla Fernandes (Author) FFUP; M E Tiritan (Author) FFUP; Pinto, MMM (Author) Other

Journal

Title: Symmetry

Vol. 9

Final page: 206

ISSN: 2073-8994

Publisher: MDPI

Indexing

ISI Web of Knowledge - 57 Citations

Scopus - 62 Citations

Other information

Authenticus ID: P-00N-47W

DOI: 10.3390/sym9100206

Abstract (EN): Given the importance of chirality in the biological response, regulators, industries and researchers require chiral compounds in their enantiomeric pure form. Therefore, the approach to separate enantiomers in preparative scale needs to be fast, easy to operate, low cost and allow obtaining the enantiomers at high level of optical purity. A variety of methodologies to separate enantiomers in preparative scale is described, but most of them are expensive or with restricted applicability. However, the use of membranes have been pointed out as a promising methodology for scale-up enantiomeric separation due to the low energy consumption, continuous operability, variety of materials and supports, simplicity, eco-friendly and the possibility to be integrated into other separation processes. Different types of membranes (solid and liquid) have been developed and may provide applicability in multi-milligram and industrial scales. In this brief overview, the different types and chemical nature of membranes are described, showing their advantages and drawbacks. Recent applications of enantiomeric separations of pharmaceuticals, amines and amino acids were reported.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 19