Biodistribution and pharmacokinetics of Mad2 siRNA-loaded EGFR-targeted chitosan nanoparticles in cisplatin sensitive and resistant lung cancer models

• Type: Article in International Scientific Journal
• Date: 2016

Authors

Nascimento, AV (Author) Other; Gattacceca, F (Author) Other; Singh, A (Author) Other; Bousbaa, H (Author) Other; Ferreira, DC (Author) FFUP; Sarmento, B (Author) Other; Amiji, MM (Author) Other

Journal

Title: Nanomedicine

Vol. 11

Pages: 767-781

ISSN: 1743-5889

Publisher: Future Medicine Ltd.

Indexing

ISI Web of Knowledge - 16 Citations

Scopus - 32 Citations

Other information

Authenticus ID: P-00K-BW5

DOI: 10.2217/nnm.16.14

Abstract (EN): Background: The present study focuses on biodistribution profile and pharmacokinetic parameters of EGFR-targeted chitosan nanoparticles (TG CS nanoparticles) for siRNA/cisplatin combination therapy of lung cancer. Material & methods: Mad2 siRNA was encapsulated in EGFR targeted and nontargeted (NTG) CS nanoparticles by electrostatic interaction. The biodistribution of the nanoparticles was assessed qualitatively and quantitatively in cisplatin (DDP) sensitive and resistant lung cancer xenograft model. Results: TG nanoparticles showed a consistent and preferential tumor targeting ability with rapid clearance from the plasma to infiltrate and sustain within the tumor up to 96 h. They exhibit a sixfold higher tumor targeting efficiency compared with the NTG nanoparticles. Conclusion: TG nanoparticles present as an attractive drug delivery platform for RNAi therapeutics against NSCLC.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 15