Cognitive impairment and dementia in Parkinson's disease: Clinical features, diagnosis, and management

• Type: Article in International Scientific Journal
• Date: 2012

Authors

Meireles, J (Author) Other; João Massano (Author) FMUP

Journal

Title: Frontiers in Neurology

Vol. MAY

ISSN: 1664-2295

Publisher: Frontiers Media

Indexing

Scopus - 105 Citations

Other information

Authenticus ID: P-008-567

DOI: 10.3389/fneur.2012.00088

Abstract (EN): Parkinson's disease (PD) is a common, disabling, neurodegenerative disorder. In addition to classical motor symptoms, non-motor features are now widely accepted as part of the clinical picture, and cognitive decline is a very important aspect of the disease, as it brings an additional significant burden for the patient and caregivers. The diagnosis of cognitive decline in PD, namely mild cognitive impairment (MCI) and dementia, can be extremely challenging, remaining largely based on clinical and cognitive assessments. Diagnostic criteria and methods for PD dementia and MCI have been recently issued by expert work groups. This manuscript has synthesized relevant data in order to obtain a pragmatic and updated review regarding cognitive decline in PD, from milder stages to dementia. This text will summarize clinical features, diagnostic methodology, and therapeutic issues of clinical decline in PD. Relevant clinical genetic issues, including recent advances, will also be approached. © 2012 Meireles and Massano.

Language: English

Type (Professor's evaluation): Scientific