Long-Term Mortality Analysis in Parkinson's Disease Treated with Deep Brain Stimulation

• Type: Article in International Scientific Journal
• Date: 2014

Authors

Rocha, S (Author) Other; Monteiro, A (Author) Other; Linhares, P (Author) FMUP; Chamadoira, C (Author) Other; Basto, MA (Author) Other; Reis, C (Author) Other; Sousa, C (Author) Other; Lima, J (Author) Other; Rosas, MJ (Author) Other; João Massano (Author) FMUP; Vaz, R (Author) Other

Journal

Title: Parkinson's Disease

Vol. 2014

Pages: 1-5

ISSN: 2090-8083

Publisher: Hindawi

Indexing

ISI Web of Knowledge - 19 Citations

Scopus - 19 Citations

Other information

Authenticus ID: P-009-BNC

DOI: 10.1155/2014/717041

Abstract (EN): Background. Few data have been published regarding long-term mortality in patients with Parkinson's disease treated with DBS. Methods. This study analyzed long-term mortality rates, causes, and correlates in PD patients treated with DBS. Results. 184 consecutive patients were included; mean follow-up was 50 months. Fifteen deaths occurred (total 8.15%, annual mortality rate 1.94%). Mean age at disease onset and at surgery was 48 +/- 2.4 and 63 +/- 1.6 years, respectively. Mean disease duration until death was 21 +/- 7.8 years. Most deaths related to stroke, myocardial infarction, other vascular/heart disorders, or severe infection; one suicide was recorded. Deceased PD patients were mostly male and had lower motor benefit after DBS, but univariate analysis failed to show significant differences regarding gender and motor benefit. Survival was 99% and 94% at 3 and 5 years. Conclusions. Long-term survival is to be expected in PD patients treated with DBS, possibly higher than previously expected. Death usually supervenes due to vascular events or infection.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5