Adenosine Receptor Ligands on Cancer Therapy: A Review of Patent Literature

• Type: Article in International Scientific Journal
• Date: 2018

Authors

Sousa, JB (Author) Other; Fresco, P (Author) FFUP; Diniz, C (Author) FFUP; Goncalves, J (Author) Other

Journal

Title: Recent Patents on Anti-Cancer Drug Discovery

Vol. 13

Pages: 40-69

ISSN: 1574-8928

Publisher: Bentham Science

Indexing

ISI Web of Knowledge - 4 Citations

Scopus - 13 Citations

Other information

Authenticus ID: P-00N-KBV

DOI: 10.2174/1574892812666171108115959

Abstract (EN): Background: Adenosine is a purine, with an adenine group and a ribose sugar, formed endogenously by ATP catabolism both intracellularly and extracellularly. Among the medicinal features of adenosine and its receptors (A(1), A(2A), A(2B) and A(3)), anticancer activity has been an intense field of research. The anticancer potential of adenosine receptor ligands has been brought to the forefront of research and evidenced in innumerous research articles and patents. Objective: The present review focuses on the patent literature from 2002 onwards (2002-May 2017). Methods: Patents were searched and downloaded from the open access patent data bases and are available online. Results: A significant number of patents (65) have been published on adenosine receptor ligands claiming anticancer activity, or presenting new methods of preparation or treatment thereof, from 2002-2017 (May). From these, 35 were published highlighting the promising attributes of compounds/methods to fight cancer. Most of the compounds act as adenosine A(3) receptor agonists, while others act as antagonists for the other adenosine receptor subtypes. The signaling events triggered by activation of adenosine A(3) receptor or by blockade of adenosine A(1), A(2A) and A(2B) receptors can reverse an environment from being pro-cancer to an anti-cancer in the body. Conclusion: The promising anticancer effects mediated by adenosine receptor ligands put them in the forefront as new drug candidates. The present compilation can be worthy to medicinal chemists, pharmacologists, biochemists and other researchers focusing on the putative anticancer activity of adenosine receptor ligands.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 30