Analytical methods for quantification of tranexamic acid in biological fluids: A review

• Type: Another Publication in an International Scientific Journal
• Date: 2017

Authors

Silva, EMP (Author) Other; Barreiros, L (Author) Other; Sa, P (Author) Other; Carlos Afonso (Author) FFUP; Kozek Langenecker, S (Author) Other; Marcela A Segundo (Author) FFUP

Journal

Title: Microchemical Journal

Vol. 134

Pages: 333-342

ISSN: 0026-265X

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 1 Citation

Scopus - 4 Citations

Other information

Authenticus ID: P-00M-XA5

DOI: 10.1016/j.microc.2017.06.020

Abstract (EN): Tranexamic acid (TXA) is a synthetic derivative of the amino acid lysine with antifibrinolytic properties. There is still a lack of pharmacokinetic and pharmacodynamic data concerning variable age groups undergoing surgeries with high blood loss. The optimum dose and administration schedules of TXA are still subject of research, aiming at a safe inhibition of fibrinolysis in the perioperative period. Hence, effective methods for determination of TXA in biological samples are needed. The aim of this review is to discuss the required sample treatment procedures and the analytical methods applied for quantification of TXA, focusing on selected derivatisation agents and internal standards. Methods comprising a separative step (GC, LC or CZE) coupled to spectrophotometric, fluorimetric and mass spectrometry detection were considered, showing a tendency for implementation of MS/MS methods in more recent reports. Detection limits ranging from 0.01 to 0.5 mu g mL(-1) in blood plasma were so far attained using LC-MS/MS.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 10