Impact of weight loss on inflammation and red blood cell biomarkers after laparoscopic gastric banding surgery

• Type: Article in International Scientific Journal
• Date: 2018

Authors

Coimbra, S (Author) Other; Ferreira, C (Author) Other; Belo, L (Author) FFUP; Rocha Pereira, P (Author) Other; Catarino, A (Author) Other; Monteiro, L (Author) Other; Cristina Catarino (Author) FFUP; Alice Santos Silva (Author) FFUP

Journal

Title: Journal of Investigative Medicine

Vol. 66

Pages: 304-308

ISSN: 1081-5589

Publisher: BMJ PUBLISHING GROUP

Indexing

ISI Web of Knowledge - 2 Citations

Scopus - 6 Citations

Other information

Authenticus ID: P-00N-HD6

DOI: 10.1136/jim-2017-000528

Abstract (EN): Adipose tissue produces several adipokines that are enrolled in different metabolic and inflammatory pathways that may disturb iron metabolism and erythropoiesis. Considering that laparoscopic adjustable gastric banding (LAGB) has not been associated with a long-term risk of malabsorption, we performed a 13-month follow-up study in severe obese patients submitted to LAGB in order to clarify its impact on inflammation, iron metabolism and on red blood cell (RBC) biomarkers. Twenty obese patients were enrolled in the study, being clinical and analytically assessed before (T0) and 13months after LAGB intervention (T1). Inflammation, iron bioavailability and RBC biomarkers were evaluated at T0 and T1. At T1, weight and anthropometric indices decreased significantly; patients showed a significant increase in mean corpuscular volume, mean corpuscular hemoglobin and mean corpuscular hemoglobin concentration (MCHC), and a reduction in red cell distribution width, ferritin, hepcidin, tumor necrosis factor-, interleukin-6 (IL-6) and C-reactive protein. Before LAGB, IL-6 correlated negatively with iron, hemoglobin concentration and MCHC; hepcidin correlated inversely with transferrin. Our data show that 13months after LAGB, the weight loss is associated with an improvement in inflammation, namely a reduction in IL-6 that may reduce hepcidin production, improving iron availability for erythropoiesis, as shown by more adequate erythrocyte hemoglobinization.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5