Unravelling exemestane: From biology to clinical prospects

• Type: Another Publication in an International Scientific Journal
• Date: 2016

Authors

Sobral, AF (Author) Other; Amaral, C (Author) Other; Georgina Correia da Silva (Author) FFUP; Teixeira, NA (Author) FFUP

Journal

Title: Journal of Steroid Biochemistry and Molecular Biology

Vol. 163

Pages: 1-11

ISSN: 0960-0760

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 11 Citations

Scopus - 19 Citations

Other information

Authenticus ID: P-00M-3A7

DOI: 10.1016/j.jsbmb.2016.03.019

Abstract (EN): Aromatase inhibitors (AIs) are anti-tumor agents used in clinic to treat hormone-dependent breast cancer. AIs block estrogens biosynthesis by inhibiting the enzyme aromatase, preventing tumor progression. Exemestane, a third-generation steroidal AI, belongs to this class of drugs and is currently used in clinic to treat postmenopausal women, due to its high efficacy and good tolerability. Here, its pharmacological and biological aspects as well as its clinical applications and comparison to other endocrine therapeutic agents, are reviewed. It is also focused the benefits and risks of exemestane, drawbacks to be overcome and aspects to be explored.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 11