Cannabinoid-induced autophagy: Protective or death role?

• Type: Another Publication in an International Scientific Journal
• Date: 2016

Authors

Costa, L (Author) Other; Amaral, C (Author) Other; Teixeira, NA (Author) FFUP; Georgina Correia da Silva (Author) FFUP; Fonseca, BM (Author) Other

Journal

Title: PROSTAGLANDINS & OTHER LIPID MEDIATORS

Vol. 122

Pages: 54-63

ISSN: 1098-8823

Publisher: Elsevier Science

Indexing

ISI Web of Knowledge - 27 Citations

Scopus - 28 Citations

Other information

Authenticus ID: P-00K-5Z6

DOI: 10.1016/j.prostaglandins.2015.12.006

Abstract (EN): Autophagy, the "self-digestion" mechanism of the cells, is an evolutionary conserved catabolic process that targets portions of cytoplasm, damaged organelles and proteins for lysosomal degradation, which plays a crucial role in development and disease. Cannabinoids are active compounds of Cannabis sativa and the most prevalent psychoactive substance is Delta(9)-tetrahydrocannabinol (THC). Cannabinoid compounds can be divided in three types: the plant-derived natural products (phytocannabinoids), the cannabinoids produced endogenously (endocannabinoids) and the synthesized compounds (synthetic cannabinoids). Various studies reported a cannabinoid-induced autophagy mechanism in cancer and non-cancer cells. In this review we focus on the recent advances in the cannabinoid-induced autophagy and highlight the molecular mechanisms involved in these processes.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 10