Impact of overweight and obesity in carotid intima-media thickness of portuguese adolescents

• Type: Article in International Scientific Journal
• Date: 2012

Authors

Leite, A (Author) Other; Santos, A (Author) Other; Monteiro, M (Author) ICBAS; Gomes, L (Author) Other; Veloso, M (Author) Other; Costa, M (Author) Other

Journal

Title: Acta Paediatrica

Vol. 101

Pages: E115-E121

ISSN: 0803-5253

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 12 Citations

Scopus - 15 Citations

Other information

Authenticus ID: P-002-CWJ

DOI: 10.1111/j.1651-2227.2011.02503.x

Abstract (EN): Aim: To measure carotid intima-media thickness (cIMT) in obese, overweight and normal-weight Portuguese adolescents, to evaluate the association between body weight early signs of atherosclerosis. Methods: Cross-sectional study, enrolling 150 adolescents (50 normal weight, 50 overweight and 50 obese) with mean age of 12.9 years. All underwent clinical, analytical and carotid common artery ultrasonographic evaluation. Results: After adjusting for systolic blood pressure and plasma High-density lipoprotein, Low-density lipoprotein and Triglycerides levels, higher mean cIMT values were observed in both overweight and obese patients, when compared to normal-weight group. Moreover, adolescents with metabolic syndrome (MS) had greater cIMT [ normal-weight: cIMT mean 0.418 mm (95% confidence intervals (95% CI) 0.399-0.437); overweight: 0.461 mm (95% CI: 0.444-0.477); obese: 0.472 mm (95% CI: 0.455-0.488); MS: 0.482 mm (95% CI: 0.444-0.520) p = 0.001]. When normal-weight and overweight adolescents were exclusively compared, differences in cIMT remained significant (p < 0.001). cIMT was positively correlated with body mass index (BMI) (r = 0.439, p < 0.001), waist circumference (r = 0.301, p = 0.018) and diastolic blood pressure (r = 0.266, p = 0.001). Conclusions: We have shown that cIMT is positively associated with BMI increase in adolescents, even in moderate overweight ranges, independent of age, gender, systolic blood pressure and plasma lipid concentrations.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7