Animal models of bariatric surgery to study mechanisms of weight loss

• Type: Another Publication in an International Scientific Journal
• Date: 2007

Authors

Monteiro, M (Author) ICBAS; Aguas, AP (Author) Other; Cardoso, MH (Author) Other

Journal

The Journal is awaiting validation by the Administrative Services.

Title: OBESITY AND METABOLISM-MILAN

Vol. 3

Pages: 214-225

ISSN: 1825-3865

Indexing

ISI Web of Knowledge - 0 Citations

Other information

Authenticus ID: P-004-654

Abstract (EN): Severe obesity is a growing epidemic for which bariatric surgery is the only treatment that has proved to cause significant and sustained weight reduction. Surgical procedures were developed to induce either food intake restriction or nutritient malabsorption, but more recently, human studies have suggested that these procedures are also able to interfere with energy homeostasis and appetite regulating pathways. Nevertheless, the metabolic and endocrine mechanisms underlying decreased food intake and increased energy expenditure in weight loss attained through surgery remains to be fully clarified. Since complete characterization of peripheral and central pathways regulating appetite and satiety is ethically impossible to perform in human patients submitted to bariatric surgery, there has been an uprising interest on the use of rodents for the study of the endocrine, neural, metabolic and molecular mechanisms of weight loss induced by bariatric surgery. Literature on bariatric surgery procedures and animal models used as tools to investigate the endocrine and metabolic pathways leading to weight loss is herein reviewed with a focus on the reported evidence for an endocrine mechanism underlying obesity surgery.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 12