The inhibitory effects of peripheral administration of peptide YY 3-36 and glucagon-like peptide-1 on food intake are attenuated by ablation of the vagal-brainstem-hypothalamic pathway

• Type: Article in International Scientific Journal
• Date: 2005

Authors

Abbott, CR (Author) Other; Monteiro, M (Author) ICBAS; Small, CJ (Author) Other; Sajedi, A (Author) Other; Smith, KL (Author) Other; Parkinson, JRC (Author) Other; Ghatei, MA (Author) Other; Bloom, SR (Author) Other

Journal

Title: Brain Research

Vol. 1044

Pages: 127-131

ISSN: 0006-8993

Publisher: Elsevier

Indexing

Scopus - 415 Citations

Other information

Authenticus ID: P-008-Q9H

DOI: 10.1016/j.brainres.2005.03.011

Abstract (EN): The vagus nerve forms a neuro-anatomical link between the gastrointestinal tract and the brain. A number of gastrointestinal hormones, including cholecystokinin and ghrelin, require an intact vagal-brainstem-hypothalamic pathway to affect CNS feeding circuits. We have shown that the effects of peripheral administration of both peptide YY3-36 (PYY3-36) and glucagon-like peptide-1 (GLP-1) on food intake and activation of hypothalamic arcuate feeding neurones are abolished following either bilateral sub-diaphragmatic total truncal vagotomy or brainstem-hypothalamic pathway transectioning in rodents. These findings suggest that the vagal-brainstem- hypothalamic pathway may also play a role in the effects of circulating PYY 3-36 and GLP-1 on food intake.

Language: English

Type (Professor's evaluation): Scientific