Strategies to Overcome Heparins' Low Oral Bioavailability

• Type: Another Publication in an International Scientific Journal
• Date: 2016

Authors

Neves, AR (Author) Other; Marta Correia da Silva (Author) FFUP; Emilia Sousa (Author) FFUP; Pinto, M (Author) Other

Journal

Title: Pharmaceuticals

Vol. 9

Final page: 37

ISSN: 1424-8247

Publisher: MDPI

Indexing

ISI Web of Knowledge - 2 Citations

Scopus - 25 Citations

Scientific classification

CORDIS: Health sciences

FOS: Medical and Health sciences

Other information

Authenticus ID: P-00K-MH1

DOI: 10.3390/ph9030037

Abstract (EN): Even after a century, heparin is still the most effective anticoagulant available with few side effects. The poor oral absorption of heparins triggered the search for strategies to achieve oral bioavailability since this route has evident advantages over parenteral administration. Several approaches emerged, such as conjugation of heparins with bile acids and lipids, formulation with penetration enhancers, and encapsulation of heparins in micro and nanoparticles. Some of these strategies appear to have potential as good delivery systems to overcome heparin's low oral bioavailability. Nevertheless, none have reached the market yet. Overall, this review aims to provide insights regarding the oral bioavailability of heparin.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 16