Further insights on tomato plant: Cytotoxic and antioxidant activity of leaf extracts in human gastric cells

• Type: Article in International Scientific Journal
• Date: 2017

Authors

Figueiredo Gonzalez, M (Author) Other; Patricia Valentao (Author) FFUP; David M Pereira (Author) FFUP; Paula B Andrade (Author) FFUP

Journal

Title: Food and Chemical Toxicology

Vol. 109

Pages: 386-392

ISSN: 0278-6915

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 6 Citations

Other information

Authenticus ID: P-00N-1PB

DOI: 10.1016/j.fct.2017.09.018

Abstract (EN): This study focused the toxicity against human gastric adenocarcinoma cells (AGS) and the antioxidant activity of hydromethanol (HME), acetone (AcE) and alkaloid (AE) extracts prepared from the leaves of tomato plant cultivars (Caramba, Valentine, Negro, Abuela, and Anairis). AE, HME and AcE extracts of all cultivars reduced cell viability, IC50 values ranging from 9 +/- 2 to 55 +/- 11, from 103 +/- 25 to 171 +/- 29 and from 291 +/- 26 to 459 +/- 14 mu g mL(-1), respectively. Moreover, both HME and AcE extracts scavenged (NO)-N-center dot (IC50 values ranged from 0.87 +/- 0.12 to 1.54 +/- 0.23 and from 0.90 +/- 0.01 to 2.23 +/- 0.14 mg mL(-1), respectively), but only HMEs was able to scavenge O-2(center dot-) showing IC50 values from 0.12 +/- <= 0.01 to 0.43 +/- 0.08 mg mL(-1). Our results demonstrate that tomato leaves, a by-product of tomato processing industry, are a valuable source of bioactive compounds, providing beneficial properties for human health.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7