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alpha-Glucosidase and alpha-amylase inhibitors from Myrcia spp.: a stronger alternative to acarbose?

Title
alpha-Glucosidase and alpha-amylase inhibitors from Myrcia spp.: a stronger alternative to acarbose?
Type
Article in International Scientific Journal
Year
2016
Authors
Figueiredo Gonzalez, M
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Grosso, C
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Journal
Vol. 118
Pages: 322-327
ISSN: 0731-7085
Publisher: Elsevier
Other information
Authenticus ID: P-00G-W5C
Abstract (EN): "Pedra hume cad" is the common name of five species of Myrcia genus used as traditional medicine for the treatment of diabetes mellitus. In this study, different extracts from Myrcia Myrcia sphaerocarpa, and Myrcia speciosa were investigated for the first time, to identify their phenolic compounds (being 3-O-rhamnoside derivatives of myricetin and quercetin the major ones) and in vitro inhibitory potential against alpha-glucosidase and alpha-amylase. These extracts inhibited 90-500 times more alpha-glucosidase (IC50 = 0.7 to 4.1 mu g ml(-1)) than acarbose and displayed a mild inhibition against alpha-amylase (IC50= 6.1 to 29 mu g mL(-1)). 2015 Elsevier B.V. All rights reserved.
Language: English
Type (Professor's evaluation): Scientific
No. of pages: 6
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