TERT biology and function in cancer: beyond immortalisation

• Type: Another Publication in an International Scientific Journal
• Date: 2017

Authors

Pestana, A (Author) Other; Vinagre, J (Author) Other; Sobrinho Simoes, M (Author) Other; Soares, P (Author) FMUP

Journal

Title: Journal of Molecular Endocrinology

Vol. 58

Pages: R129-R146

ISSN: 0952-5041

Publisher: BioScientifica Ltd.

Indexing

ISI Web of Knowledge - 45 Citations

Scopus - 52 Citations

Other information

Authenticus ID: P-00M-FCM

DOI: 10.1530/jme-16-0195

Abstract (EN): Evasion of replicative senescence and proliferation without restriction, sometimes designated as immortalisation, is one of the hallmarks of cancer that may be attained through reactivation of telomerase in somatic cells. In contrast to most normal cells in which there is lack of telomerase activity, upregulation of TERT transcription/activity is detected in 80-90% of malignant tumours. In several types of cancer, there is a relationship between the presence of TERT promoter mutations, TERT mRNA expression and clinicopathological features, but the biological bridge between the occurrence of TERT promoter mutations and the aggressive/invasive features displayed by the tumours remains unidentified. We and others have associated the presence of TERT promoter mutations with metastisation/survival in several types of cancer. In follicular cell-derived thyroid cancer, such mutations are associated with worse prognostic features (age of patients, tumour size and tumour stage) as well as with distant metastases, worse response to treatment and poorer survival. In this review, we analyse the data reported in several studies that imply TERT transcription reactivation/activity with cell proliferation, tumour invasion and metastisation. A particular attention is given to the putative connections between TERT transcriptional reactivation and signalling pathways frequently altered in cancer, such as c-MYC, NF-kappa B and B-Catenin.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 18