Incident risk factors as predictors of HIV seroconversion in the Lisbon cohort of men who have sex with men: first results, 2011-2014

• Type: Article in International Scientific Journal
• Date: 2015

Authors

Meireles, P (Author) Other; Lucas, R (Author) FMUP; Carvalho, C (Author) Other; Fuertes, R (Author) Other; Brito, J (Author) Other; Campos, MJ (Author) Other; Mendao, L (Author) Other; Barros H (Author) FMUP

Journal

Title: Eurosurveillance

Vol. 20

Pages: 45-56

ISSN: 1560-7917

Publisher: European Centre for Disease Prevention and Control (ECDC)

Indexing

ISI Web of Knowledge - 15 Citations

Scopus - 21 Citations

Other information

Authenticus ID: P-00A-C3C

DOI: 10.2807/1560-7917.es2015.20.14.21091

Abstract (EN): HIV incidence in men who have sex with men (MSM) is increasing in western countries, including Portugal. We aimed to estimate HIV incidence and to assess how individual short-term changes in exposures over time predict seroconversion. We evaluated participants of an open cohort of HIV-negative MSM enrolled after testing at a community-based voluntary HIV counselling and testing centre in Lisbon. At each evaluation a structured questionnaire was completed and HIV status was ascertained using rapid followed by confirmatory testing. Between April 2011 and February 2014, 804 MSM were followed for a total of 893 person-years. Predictors of HIV seroconversion were identified using Poisson generalised linear regression. The overall seroincidence was 2.80/100 person-years (95% confidence interval: 1.89-4.14). Men who seroconverted had a higher mean number of tests per year. Seroconversions were significantly associated with partner disclosure of HIV status during follow-up, newly-adopted unprotected anal intercourse (UAI) with a steady partner and being newly-diagnosed with syphilis during follow-up. Likewise, sexual intercourse with HIV-positive men, having an HIV-positive steady partner at least once during follow-up and persistent UAI with occasional partners were predictors of seroconversion. High HIV incidence in this cohort is likely driven by short-term contextual and behavioural changes during follow-up.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 12