Alcohol Intake and Systemic Markers of Inflammation-Shape of the Association According to Sex and Body Mass Index

• Type: Article in International Scientific Journal
• Date: 2010

Authors

Oliveira A (Author) FMUP; Rodriguez Artalejo, F (Author) Other; Lopes C (Author) FMUP

Journal

Title: Alcohol and Alcoholism

Vol. 45 No. 2

Pages: 119-125

ISSN: 0735-0414

Publisher: Oxford University Press

Indexing

ISI Web of Knowledge - 50 Citations

Scopus - 54 Citations

Other information

Authenticus ID: P-003-8D2

DOI: 10.1093/alcalc/agp092

Abstract (EN): Methods: Individuals aged >= 18 years were randomly selected from the population of Porto, Portugal (70% of participation). A total of 840 women and 490 men with reliable information on inflammatory markers and alcohol intake, obtained from a validated food frequency questionnaire, were studied. Associations and their respective trends were estimated from generalized linear models, with adjustment for potential confounders. Analyses were stratified by sex and BMI. Results: In women, adjusted hs-CRP levels (mg/l) were 2.69 in non-drinkers, 2.25 in drinkers of > 0-15 g alcohol/day, 2.32 in drinkers of > 15-30 g alcohol/day and 3.18 in drinkers of > 30 g alcohol/day (P-value for the quadratic trend < 0.001). In men, the association between alcohol intake and hs-CRP was positive and linear (P-value for the linear trend = 0.014). Alcohol intake was also positively and linearly associated with uric acid in each sex. Body weight modified these associations, which remained statistically significant only in normal-weight (BMI < 25 kg/m(2)) women and overweight (BMI >= 25 kg/m(2)) men for hs-CRP, and in normal-weight individuals for uric acid. No significant association between alcohol intake and leukocyte count was found. Conclusions: The association of alcohol intake with hs-CRP was J-shaped in women but positive and linear-shaped in men. Alcohol intake was directly associated with uric acid in men and women. BMI modifies the effect of alcohol on hs-CRP and uric acid levels in each sex.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7