Histological Outcomes and Predictive Value of Faecal Markers in Moderately to Severely Active Ulcerative Colitis Patients Receiving Infliximab

• Type: Article in International Scientific Journal
• Date: 2016

Authors

Magro F (Author) FMUP; Lopes, SI (Author) Other; Lopes, J (Author) Other; Portela, F (Author) Other; Cotter, J (Author) Other; Lopes, S (Author) Other; Moreira, MJ (Author) Other; Lago, P (Author) Other; Peixe, P (Author) Other; Albuquerque, A (Author) Other; Rodrigues, S (Author) Other; Silva, MR (Author) Other; Monteiro, P (Author) Other; Lopes, C (Author) Other; Monteiro, L (Author) Other; Macedo G (Author) FMUP; Veloso, L (Author) Other; Dias C (Author) FMUP; Afonso, J (Author) FMUP; Geboes, K (Author) Other; Carneiro F (Author) FMUP

Journal

Title: Journal of Crohn's and Colitis

Vol. 10

Pages: 1407-1416

ISSN: 1873-9946

Publisher: Oxford University Press

Indexing

ISI Web of Knowledge - 36 Citations

Scopus - 36 Citations

Other information

Authenticus ID: P-00M-G98

DOI: 10.1093/ecco-jcc/jjw112

Abstract (EN): Background and Aims: Histological healing has emerged as a promising therapeutic goal in ulcerative colitis. This is especially important in the context of biological therapies. The objectives of the present study were to investigate the ability of infliximab to induce histological remission in ulcerative colitis [UC] patients and to explore the utility of faecal calprotectin and lactoferrin in predicting histological activity. Methods: Multi-centre, single-cohort, open-label, 52-week trial including moderately to severely biological-naive UC patients receiving intravenous infliximab [5 mg/kg]. The primary outcome was the proportion of patients with histological remission [Geboes index <= 3.0] after 8 weeks of treatment, scored by two independent pathologists. Results: Twenty patients were included. The rate of histological remission increased from 5% at baseline to 15% and 35% at Week 8 and Week 52, respectively. At Week 8, 40% of patients were in clinical remission [Mayo <= 2] and 45% achieved mucosal healing [Mayo endoscopy subscore 0-1].At Week 52, 25% of patients had clinical, endoscopic and histological remission. Faecal calprotectin and lactoferrin showed the highest correlation with histological activity at Week 8 (area under the curve [AUC] 94%, p = 0.017; and 96%, p = 0.013, respectively) and both markers revealed an excellent positive predictive value for this outcome at this time point [100%, p = 0.017; and 94%, p = 0.013, respectively]. Conclusions: Infliximab was able to induce histological remission. There was a good agreement between histology and faecal biomarkers. Faecal calprotectin and lactoferrin were good predictors of histological remission. Our data support inclusion of histology as a treatment target complementary to endoscopy in clinical trials when evaluating therapeutic response in UC.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 10