Glycogenic hepatopathy in young adults: a case series

• Type: Article in International Scientific Journal
• Date: 2016

Authors

Silva, M (Author) Other; Marques, M (Author) Other; Cardoso, H (Author) Other; Rodrigues, S (Author) Other; Andrade, P (Author) Other; Peixoto, A (Author) Other; Pardal, J (Author) Other; Lopes, J (Author) Other; Carneiro F (Author) FMUP; Macedo G (Author) FMUP

Journal

Title: Revista Espanola de Enfermedades Digestivas

Vol. 108

Pages: 672-675

ISSN: 1130-0108

Publisher: Aran Ediciones SA

Indexing

ISI Web of Knowledge - 20 Citations

Scopus - 1 Citation

Other information

Authenticus ID: P-00M-7XV

DOI: 10.17235/reed.2016.3934/2016

Abstract (EN): Glycogenic hepatopathy is a rare and underecognized complication in long-standing poorly controlled type 1 diabetes mellitus patients. This is a distinct entity from other causes of hepatomegaly and elevated liver enzymes in diabetics, such as nonalcoholic fatty liver disease. Glycogenic hepatopathy is characterized by the combination of poorly controlled diabetes, acute liver injury with marked elevation in serum aminotransferases, and the characteristic histological features on liver biopsy. It is important to distinguish this entity as it has the potential for resolution following improved glycemic control. In this report, we describe four cases of adult patients presenting elevated serum transaminases and hepatomegaly with a history of poorly controlled type I diabetes mellitus. One of the patients had also elevated amylase and lipase in the serum, without clinical or imagiologic evidence of acute pancreatitis. Liver biopsy was performed in all patients and revealed glycogenic hepatopathy. Clinician's awareness of glycogenic hepatopathy should prevent diagnostic delay or misdiagnosis and will provide better insight and management for this condition.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 4