Experimental study of tuberculosis: From animal models to complex cell systems and organoids

• Type: Another Publication in an International Scientific Journal
• Date: 2017

Authors

Fonseca, KL (Author) Other; Rodrigues, P (Author) ICBAS; Olsson, IAS (Author) Other; Saraiva, M (Author) Other

Journal

Title: PLoS Pathogens

Vol. 13

Final page: e1006421

ISSN: 1553-7366

Publisher: Public Library of Science

Indexing

ISI Web of Knowledge - 13 Citations

Scopus - 31 Citations

Other information

Authenticus ID: P-00M-YYN

DOI: 10.1371/journal.ppat.1006421

Abstract (EN): Tuberculosis (TB) is a devastating disease to mankind that has killed more people than any other infectious disease. Despite many efforts and successes from the scientific and health communities, the prospect of TB elimination remains distant. On the one hand, sustainable public health programs with affordable and broad implementation of anti-TB measures are needed. On the other hand, achieving TB elimination requires critical advances in three areas: vaccination, diagnosis, and treatment. It is also well accepted that succeeding in advancing these areas requires a deeper knowledge of host-pathogen interactions during infection, and for that, better experimental models are needed. Here, we review the potential and limitations of different experimental approaches used in TB research, focusing on animal and human-based cell culture models. We highlight the most recent advances in developing in vitro 3D models and introduce the potential of lung organoids as a new tool to study Mycobacterium tuberculosis infection.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 13