Adrenergic influences on the control of blood-brain barrier permeabilit

• Type: Article in International Scientific Journal
• Date: 1991

Authors

Sarmento A (Author) FMUP; Borges, Nuno (Author) Other; Azevedo, I (Author) Other

Journal

Title: Naunyn-Schmiedeberg's Archives of Pharmacology

Vol. 343

Pages: 633-637

ISSN: 0028-1298

Publisher: Springer Nature

Indexing

Scopus - 47 Citations

Other information

Authenticus ID: P-00F-GND

DOI: 10.1007/bf00184295

Abstract (EN): The central adrenergic innervation of the cerebral microvessels may play a role in the control of blood-brain barrier permeability. To pursue the study of this hypothesis we investigated the effect of noradrenaline on both the permeability of the blood-brain barrier to sodium fluorescein and on the pinocytotic activity of cerebral endothelial cells in the rat. Noradrenaline, stereotactically injected in the right lateral cerebral ventricle, significantly increased the cerebral extraction ratio of sodium fluorescein in a dose-dependent way. The same effect was induced by phenylephrine. Prostaglandin F2¿ had no significant effect on the passage of sodium fluorescein through the blood-brain barrier. The effect of noradrenaline (150 ¿g) on the cerebral extraction ratio of sodium fluorescein was totally blocked by phenoxybenzamine (25 mg/kg i.p., 24 h before noradrenaline). Noradrenaline (150 ¿g) significantly increased the pinocytotic activity of cerebral endothelial cells. Phenoxybenzamine (as above) reduced the effect of noradrenaline on pinocytosis. It is concluded that noradrenaline increases the blood-brain barrier's permeability to sodium fluorescein, most probably through an effect on alpha adrenoceptors. The increase induced in the blood-brain barrier's permeability by noradrenaline seems to be due, at least in part, to an increase in the pinocytotic activity of endothelial cells. © 1991 Springer-Verlag.

Language: English

Type (Professor's evaluation): Scientific