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INFLUENCE OF ELECTRICAL-STIMULATION OF LOCUS-CERULEUS ON THE RAT BLOOD-BRAIN-BARRIER PERMEABILITY TO SODIUM FLUORESCEIN

Title
INFLUENCE OF ELECTRICAL-STIMULATION OF LOCUS-CERULEUS ON THE RAT BLOOD-BRAIN-BARRIER PERMEABILITY TO SODIUM FLUORESCEIN
Type
Article in International Scientific Journal
Year
1994
Authors
Sarmento A
(Author)
FMUP
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Borges, Nuno
(Author)
Other
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Deolinda Lima
(Author)
FMUP
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Journal
Title: Acta NeurochirurgicaImported from Authenticus Search for Journal Publications
Vol. 127
Pages: 215-219
ISSN: 0001-6268
Publisher: Springer Nature
Other information
Authenticus ID: P-001-KGW
Abstract (EN): The role of central adrenergic innervation of the brain capillaries is still a matter of discussion. The hypothesis that these nerves control the blood-brain barrier permeability was tested by electrically stimulating the locus coeruleus, the major central adrenergic nucleus, in the anaesthetized rat. Frequencies of 5, 15, and 30 Hz were used. A frequency dependent increase in blood-brain barrier permeability to sodium fluorescein was verified. Prior administration of the alpha-adrenoceptor antagonist phenoxybenzamine (10 mg/kg i.p., 24 h before electrical stimulation) totally blocked the effect of 15 Hz stimulation. The same dose of pindolol (a beta-adrenoceptor antagonist) given 1 h before electrical stimulation potentiated the effect of 5 Hz stimulation. Thus, blood-brain barrier permeability is increased, in a frequency dependent manner, by electrical stimulation of the locus coeruleus. The results obtained with phenoxybenzamine and pindolol suggest an opposite effect of alpha and beta-adrenoceptors on the control of sodium fluorescein transport through the blood-brain barrier.
Language: English
Type (Professor's evaluation): Scientific
No. of pages: 5
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