Effect of mechanogated membrane ion channel blockers on experimental traumatic brain oedema

• Type: Article in International Scientific Journal
• Date: 1998

Authors

Vaz, R (Author) Other; Sarmento, A (Author) Other; Borges, Nuno (Author) FCNAUP; Cruz, C (Author) Other; Azevedo, I (Author) Other

Journal

Title: Acta Neurochirurgica

Vol. 140

Pages: 371-375

ISSN: 0001-6268

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 15 Citations

Scopus - 14 Citations

Other information

Authenticus ID: P-001-8NS

DOI: 10.1007/s007010050111

Abstract (EN): Traumatic head injury leads to marked swelling of endothelial cells, both in human patients and in Marmarou's rat model. We used this model to test the hypothesis of mechanogated ion channels being involved in the formation of traumatic brain oedema. All mechanogated channel blockers tested (gadolinium, amiloride, gentamicin) significantly reduced traumatic brain oedema evaluated by Evans blue extraction ratio, either when given 15 minutes before or 30 minutes after induction of trauma (evaluation 2 hours after trauma). These results clearly support our hypothesis, opening a new way for the investigation of the treatment of a clinical situation endowed with high morbidity and mortality.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5