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Effect of mechanogated membrane ion channel blockers on experimental traumatic brain oedema

Title
Effect of mechanogated membrane ion channel blockers on experimental traumatic brain oedema
Type
Article in International Scientific Journal
Year
1998
Authors
Vaz, R
(Author)
Other
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Sarmento, A
(Author)
Other
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Borges, Nuno
(Author)
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Cruz, C
(Author)
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Azevedo, I
(Author)
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Journal
Title: Acta NeurochirurgicaImported from Authenticus Search for Journal Publications
Vol. 140
Pages: 371-375
ISSN: 0001-6268
Publisher: Springer Nature
Other information
Authenticus ID: P-001-8NS
Abstract (EN): Traumatic head injury leads to marked swelling of endothelial cells, both in human patients and in Marmarou's rat model. We used this model to test the hypothesis of mechanogated ion channels being involved in the formation of traumatic brain oedema. All mechanogated channel blockers tested (gadolinium, amiloride, gentamicin) significantly reduced traumatic brain oedema evaluated by Evans blue extraction ratio, either when given 15 minutes before or 30 minutes after induction of trauma (evaluation 2 hours after trauma). These results clearly support our hypothesis, opening a new way for the investigation of the treatment of a clinical situation endowed with high morbidity and mortality.
Language: English
Type (Professor's evaluation): Scientific
No. of pages: 5
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