Evaluation of implant osseointegration with different regeneration techniques in the treatment of bone defects around implants: an experimental study in a rabbit model

• Type: Article in International Scientific Journal
• Date: 2011

Authors

Guerra, I (Author) Other; Branco, FM (Author) Other; Vasconcelos M (Author) FMDUP; Américo Afonso (Author) FMDUP; Maria Helena Figueiral (Author) FMDUP; Zita, R (Author) Other

Journal

Title: Clinical Oral Implants Research

Vol. 22 No. 3

Pages: 314-322

ISSN: 0905-7161

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 17 Citations

Scopus - 15 Citations

Other information

Authenticus ID: P-002-TPA

DOI: 10.1111/j.1600-0501.2010.02002.x

Abstract (EN): Aim The aim of this study was to evaluate the osseointegration of implants placed in areas with artificially created bone defects, using three bone regeneration techniques. Material and methods The experimental model was the rabbit femur (16), where bone defects were created and implants were placed. The peri-implant bone defects were filled with a deproteinized bovine bone mineral, NuOss (TM) (N), NuOss (TM) combined with plasma rich in growth factors (PRGF) (N+PRGF), NuOss (TM) covered by an RCM6 membrane (N+M), or remained unfilled (control group [C]). After 4 and 8 weeks, the animals were euthanized and bone tissue blocks with the implants and the surrounding bone tissue were removed and processed according to a histological protocol for hard tissues on non-decalcified ground sections. The samples were studied by light and electron scanning microscopy, histometric analysis was performed to assess the percentage of bone in direct contact with the implant surface and a statistical analysis of the results was performed. Results In the samples analyzed 4 weeks after implantation, the percentage of bone tissue in direct contact with the implant surface for the four groups were 57.66 +/- 24.39% (N), 58.62 +/- 20.37% (N+PRGF), 70.82 +/- 20.34 % (N+M) and 33.07 +/- 5.49% (C). In the samples with 8 weeks of implantation time, the percentage of bone in direct contact was 63.35 +/- 27.69% (N), 58.42 +/- 24.77% (N+PRGF), 78.02 +/- 15.13% (N+M) and 40.28 +/- 27.32% (C). In terms of the percentage of bone contact, groups N and N+M presented statistically significant differences from group C in the 4-week trial test (P < 0.05; ANOVA). For the 8-week results, only group N+M showed statistically significant differences when compared with group C (P < 0.05; ANOVA). Conclusion In conclusion, the NuOss (TM) granules/RCM6 membrane combination presented a percentage of bone contact with the implant surface statistically greater than in the other groups. To cite this article:Guerra I, Branco FM, Vasconcelos M, Afonso A, Figueiral H, Zita R. Evaluation of implant osseointegration with different regeneration techniques in the treatment of bone defects around implants: an experimental study in a rabbit model.Clin. Oral Impl. Res. 22, 2011; 314-322.doi: 10.1111/j.1600-0501.2010.02002.x.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9