Pathogenesis of Gastric Cancer: Genetics and Molecular Classification

• Type: Another Publication in an International Scientific Journal
• Date: 2017

Authors

Figueiredo C (Author) FMUP; Camargo, MC (Author) Other; Leite, M (Author) Other; Fuentes Panana, EM (Author) Other; Rabkin, CS (Author) Other; Machado JC (Author) FMUP

Journal

Title: Current Topics in Microbiology and Immunology

Vol. 21

Pages: 277-304

ISSN: 0070-217X

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 73 Citations

Scopus - 74 Citations

Other information

Authenticus ID: P-00M-C6A

DOI: 10.1007/978-3-319-50520-6

Abstract (EN): Gastric cancer is the fifth most incident and the third most common cause of cancer-related death in the world. Infection with Helicobacter pylori is the major risk factor for this disease. Gastric cancer is the final outcome of a cascade of events that takes decades to occur and results from the accumulation of multiple genetic and epigenetic alterations. These changes are crucial for tumor cells to expedite and sustain the array of pathways involved in the cancer development, such as cell cycle, DNA repair, metabolism, cell-to-cell and cell-to-matrix interactions, apoptosis, angiogenesis, and immune surveillance. Comprehensive molecular analyses of gastric cancer have disclosed the complex heterogeneity of this disease. In particular, these analyses have confirmed that Epstein-Barr virus (EBV)-positive gastric cancer is a distinct entity. The identification of gastric cancer subtypes characterized by recognizable molecular profiles may pave the way for a more personalized clinical management and to the identification of novel therapeutic targets and biomarkers for screening, prognosis, prediction of response to treatment, and monitoring of gastric cancer progression.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 28